It’s 1923, and Florence Harding has a problem: her husband, President Warren G. Harding. Under the hanging threat of his sex scandals and financial misdeeds, the Hardings embark on a cross-country train tour to generate good press.

But trouble comes along for the ride in the form of two of Warren’s blackmailing mistresses, a scheming Second Lady who’s looking to move up, an incompetent herbalist who somehow became Assistant Surgeon General, a debauched newspaper publisher brandishing a legendary cursed diamond, and a ill-tempered pet squirrel named Handsome Pete.

And the source of all the chaos is always charming, useless Warren… whom Florence might just have to deal with once and for all.